Jardiance is approved for managing blood sugar in type 2 diabetes, heart failure, and chronic kidney disease, so using it strictly for weight loss is considered offlabel
Eur J Heart Fail 22:196213 Khan MS, Fonarow GC, McGuire DK, Hernandez AF, Vaduganathan M, Rosenstock J, Handelsman Y, Verma S, Anker SD, McMurray JJV, Kosiborod MN, Butler J (2020) Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure: The Need for Further Evidence Generation and Practice Guidelines Optimization
102 The latter, glucagon, is a basic glucose-regulating hormone with catabolic and thermogenic actions, but it also increases glucose levels and the risk of gluconeogenesis
In advanced cases with borderline resectable disease, patients could potentially receive therapies before the surgery to increase the chances of successful surgical removal of the tumor
If significant side effects materialize, the high (and rising) sales of GLP-1 for weight loss treatment will likely attract the attention of plaintiff lawyers and litigation funders